Table 2.

Minor allele frequencies (MAFs) of the polymorphisms studied in Polish patients with rheumatoid arthritis and healthy individuals.

Polymorphism	Minor Allele	MAF RA Patients	MAF Controls
NF-κB1 (rs28362491, −94 del/ins ATTG)	del	0.423	0.385
TLR2 (rs111200466, −196/−174 del/ins)	del	0.168	0.179
TLR4 (rs4986790, 13843 A > G)	G	0.077	0.065
TLR4 (rs4986791, 14143 C > T)	T	0.077	0.074
TLR9 (rs5743836; −1237 C > T)	C	0.135	0.083
TLR9 (rs187084; −1486 T > C)	T	0.495	0.131

Of the six polymorphisms studied, 2 single nucleotide polymorphisms (SNP) within the TLR9 gene (rs5743836, −1237 C > T and rs187084, −1486 T > C) were found to be associated with predisposition to the disease. Distribution of alleles and genotypes of the TLR2, TLR4, TLR9 and NF-κB1 genes is given in Table 3.