Table 1.

Drug provocation tests.

Definition: Controlled administration of a drug to diagnose drug hypersensitivity and the last step for accurate recognition of drug hypersensitivity reactions if the previous diagnostic evaluations are negative or unavailable.

Requirements: •Trained personnel, who know how to perform tests, are ready to recognize and treat symptoms and signs of a hypersensitivity reaction •Equipment for emergency resuscitations

Methods •Informed consent •Commercial agents are usually used •Route of administration: Oral, parenteral, cutaneous, bronchial, etc. •Starting dose depends on severity and immediate/non-immediate timing of index reaction (1/10000–1/10) •Interval: 30–90 min