Table 2.

Advantages and disadvantages of Drug provocation tests.

Advantages	Disadvantages
Confirmation or exclusion of diagnosis of drug hypersensitivity	Potentially dangerous
Less use of more expensive alternatives	DPT protocol is chosen based on patients′/parents′ report about the reaction suffered
Less use of broad spectrum antibiotics, decreased risk of antibiotic resistance	False positive and false negative results may occur
Reduced cost of drug allergy algorithm	Cofactors may be absent
Generally good safety profile	Potential risk of resensitization
Acceptable for most patients	Although gold standard, many contraindications to perform DPT may be present
Avoidance of unnecessary desensitizations	Lack of standardized protocols, especially for non-immediate reactions
Provision of safe alternative	Subjective symptoms could be difficult to interpret
Decreased social burden of drug allergy	Lack of objective and reliable biomarkers (e.g., serum tryptase)
	Negative results may not be sufficient to reuse the culprit drug
	Need experienced personnel and well-established clinical settings