Table 2.

Number and frequency of molecular alterations in different age groups of CRC patients.

Gene	<50	%	50–60	%	60–70	%	70–80	%	>80	%	p
Case No/%	63	4.3	252	17.1	321	21.8	560	38.0	279	18.9
APC	14	22.2	75	29.8	94	29.3	178	31.8	77	27.6	0.482
P53	17	27.0	78	31.0	99	30.8	164	29.3	72	25.8	0.645
KRAS	22	34.9	98	38.9	129	40.2	228	40.7	112	40.1	0.92
NRAS	5	7.9	6	2.4	13	4.0	23	4.1	15	5.4	0.263
HRAS	4	6.3	3	1.2	8	2.5	5	0.9	5	1.8	0.018
FBXW7	4	6.3	19	7.5	18	5.6	42	7.5	26	9.3	0.537
PIK3CA	10	15.9	29	11.5	43	13.4	93	16.6	32	11.5	0.184
AKT1	2	3.2	2	0.8	4	1.2	3	0.5	2	0.7	0.272
PTEN	4	6.3	2	0.8	1	0.3	5	0.9	0	0.0	<0.001
TGFbR	3	4.8	4	1.6	12	3.7	20	3.6	8	2.9	0.513
SMAD4	4	6.3	12	4.8	13	4.0	17	3.0	13	4.7	0.564
BRAF	3	4.8	9	3.6	12	3.7	26	4.6	12	4.3	0.945
MSI-high	16	25.4	20	7.9	29	9.0	53	9.5	30	10.8	<0.001