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. 2017 Jul 9;18(7):1471. doi: 10.3390/ijms18071471

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Implications of miRNA-mRNA pairs in selected pathogen-induced signaling pathways: A total of 6 miRNAs and their mRNA targets were analyzed for the potential of their involvement in signaling pathways using Cytoscape 3.2.0 (www.cytoscape.org). We have presented only a few selected pathways, which may be involved in pathogen-induced signaling. Only experimentally validated targets with strong evidence based on a combination of reporter assay, Western blot analysis, and quantitative PCR are presented. Dark green color indicates up-regulated and red color depicts down-regulated miRNAs during rickettsial infection. Yellow color represents the target genes for both up- and down-regulated miRNAs and lines indicate regulatory relationships between the miRNAs and genes. Selected genes and their involvement in respective signaling pathways are depicted in the outer circle. There are currently no validated targets with strong evidence for miR-548-3p in the databases MirTarBase [22] and DIANA-TarBase [23] used in this study.