Table 1.

List of human miRNAs significantly up and down regulated in human dermal microvascular endothelial cells (HMECs) upon infection with R. rickettsii strain Sheila Smith.

miRNA Name	Consensus Sequence	Fold Change
Up Regulated miRNAs		3 h	24 h
miR-129-5p	CUUUUUGCGGUCUGGGCUUGC	19.8	9.5
miR-200a-3p	UAACACUGUCUGGUAACGAUGU	15.9	8.8
miR-297	AUGUAUGUGUGCAUGUGCAUG	15.6	18.6
miR-200b-3p	UAAUACUGCCUGGUAAUGAUGA	14.7	10.2
miR-595	GAAGUGUGCCGUGGUGUGUCU	10.4	9.3
miR-574-5p	UGAGUGUGUGUGUGUGAGUGUGU	7.2	8.6
miR-647	GUGGCUGCACUCACUUCCUUC	4.1	5.0
miR-615-3p	UCCGAGCCUGGGUCUCCCUCUU	3.9	4.3
miR-1224-5p	GUGAGGACUCGGGAGGUGG	3.5	4.2
miR-1238-3p	CUUCCUCGUCUGUCUGCCCC	2.2	2.2
miR-196a-5p	UAGGUAGUUUCAUGUUGUUGGG	3.1	-
miR-616-3p	AGUCAUUGGAGGGUUUGAGCAG	3.9	-
miR-760	CGGCUCUGGGUCUGUGGGGA	3.7	-
miR-1275	GUGGGGGAGAGGCUGUC	2.1	-
miR-146a-5p	UGAGAACUGAAUUCCAUGGGUU	-	13.7
miR-631	AGACCUGGCCCAGACCUCAGC	-	12.6
miR-661	UGCCUGGGUCUCUGGCCUGCGCGU	-	7.7
miR-766-3p	ACUCCAGCCCCACAGCCUCAGC	-	4.6
miR-1273a	GGGCGACAAAGCAAGACUCUUUCUU	-	2.8
miR-1202	GUGCCAGCUGCAGUGGGGGAG	-	2.7
miR-943	CUGACUGUUGCCGUCCUCCAG	-	2.7
miR-1250-5p	ACGGUGCUGGAUGUGGCCUUU	-	2.6
miR-1229-3p	CUCUCACCACUGCCCUCCCACAG	-	2.5
Down Regulated miRNAs
miR-301b-3p	CAGUGCAAUGAUAUUGUCAAAGC	−3.3	−2.8
miR-548a-3p	CAAAACUGGCAAUUACUUUUGC	−3.1	−3.1
miR-377-3p	AUCACACAAAGGCAACUUUUGU	−2.1	−3.2
miR-602	GACACGGGCGACAGCUGCGGCCC	−2.1	-
miR-802	CAGUAACAAAGAUUCAUCCUUGU	−2.2	-
miR-376b-3p	AUCAUAGAGGAAAAUCCAUGUU	-	−2.9
miR-216b-5p	AAAUCUCUGCAGGCAAAUGUGA	-	−2.4
miR-216a-5p	UAAUCUCAGCUGGCAACUGUGA	-	−2.4
miR-410-3p	AAUAUAACACAGAUGGCCUGU	-	−2.3
miR-29b-3p	UAGCACCAUUUGAAAUCAGUGUU	-	−2.1

‘-’ indicates fold change <2 and/or p > 0.05.