Figure 1.

Schematic depiction of lncRNAs involved in the control of MYC transcriptional program. In the upper part, a graphic representation of the MYC genomic locus is shown, with the lncRNAs (the “red worms”) involved in the regulation of MYC transcription, MYC mRNA stability, MYC translation and MYC protein stability. Once the MYC protein is formed it heterodimerizes with MAX to form a transcriptional competent factor that binds to the E-box in order to control gene expression. The lower part of the graphic shows the lncRNAs that are transcriptionally regulated by MYC. Some MYC regulated lncRNAs are also able to affect the transcriptional activity of MYC itself. Most of the lncRNAs regulated by MYC have been described to influence growth, proliferation, survival or motility of cancer cells.