Figure 1.

Changes in nuclear morphology may be associated with epigenetic modifications and deregulation of gene expression. (A) Immunocytochemistry of a head and neck squamous carcinoma (HNSCC) tumor sample stained for acetyl-H3 (Lys9). Note differences in the nuclear size and high levels of histone acetylation (red arrows, dark brown); (B) Immunofluorescence of an HNSCC tumor sample stained for acetyl-H3 (Lys9). Note differences in the nuclear size and protein accumulation depicted by yellow arrows. Scale bars represent 50 μm. Experimental procedure is described in [88].