Table 1.

Studies reporting the validated target genes for miRNAs in bladder cancer cells.

miRNA	Expression	Target Genes	Pathway	Reference
miR-9	↑	CBX7		[40]
miR-9	↑	LASS2		[41]
miR-19a	↑	PTEN	AKT/PKB signaling	[42]
miR-21	↑	BCL-2	PI3K-AKT	[36]
miR-24-3p	↑	DEDD		[43]
miR-92	↑	GSK3β	Wnt/c-myc/MMP7 signaling	[44]
miR-92b	↑	DAB2IP	EMT	[32]
miR-96	↑	CDKN1A		[45]
miR-129	↑	SOX4		[25]
miR-130b	↑	PTEN	PI3K/AKT signaling	[46]
miR-135a	↑	PHLPP2, FOXO1	AKT signaling	[47]
miR-137	↑	PAQR3		[48]
miR-138-5p	↑	BIRC5		[49]
miR-150	↑	PDCD4		[50]
miR-155	↑	DMTF1		[51]
miR-182-5p	↑	RECK, Smad4		[52]
miR-193a-3p	↑	LOXL4, SRSF2	Oxidative Stress	[53]
miR-200	↑	ERRFI-1	EGFR inhibitor resistance	[54]
miR-222	↑	PPP2R2A	PPP2R2A/AKT/mTOR signaling	[55]
miR-301a/b	↑	PTEN	PI3K/AKT signaling	[46]
miR-495	↑	PTEN		[56]
miR-1	↓	LASP1		[57]
miR-1	↓	TAGLN2		[58]
miR-1	↓	SRSF9		[59]
miR-1	↓	PTMA, PNP		[60]
miR-1	↓	UCA1		[61]
miR-23b	↓	Zeb-1	EMT	[33]
miR-24	↓	CARMA3	EMT	[62]
miR-24-1	↓	FOXM1		[63]
miR-26a	↓	HMGA1		[64]
miR-26a-5p	↓	PLOD2		[65]
miR-26b-5p	↓	PLOD2		[65]
miR-27a	↓	SLC7A11	Glutathione biosynthesis	[66]
miR-27a	↓	RUNX-1		[67]
miR-29c	↓	BCL-2, MCL1		[68]
miR-29c	↓	CDK6	G1 phase arrest	[69]
miR-31	↓	ITGA5	AKT and ERK	[70]
miR-34a	↓	Cdk-6, SIRT-1		[71]
miR-34a	↓	CD44	EMT	[72]
miR-34a	↓	HNF4G		[73]
miR-99a	↓	FGFR3		[74]
miR-99a	↓	FGFR3		[75]
miR-100	↓	FGFR3		[74]
miR-100	↓	mTOR		[76]
miR-101	↓	COX-2		[77]
miR-101	↓	VEGF-C		[78]
miR-101	↓	c-FOS		[79]
miR-106a	↓	cyclin D1/CDK6		[80]
miR-122	↓	VEGFC	mTOR and AKT	[81]
miR-124	↓	Cdk4		[82]
miR-124	↓	UHRF1		[83]
miR-124-3p	↓	ROCK1	EMT	[34]
miR-125b	↓	E2F3	E2F3–Cyclin A2 signaling	[84]
miR-125b	↓	MMP13		[85]
miR-125b	↓	SphK1	G1 phase arrest	[86]
miR-126	↓	ADAM9		[87]
miR-126	↓	PIK3R2	PI3K/AKT signaling	[88]
miR-128	↓	VEGF-C		[89]
miR-1280	↓	ROCK1		[90]
miR-130b-3p	↓	PTEN	PI3K and integrin β1/FAK signaling	[91]
miR-133a	↓	LASP1		[57]
miR-133a	↓	TAGLN2		[58]
miR-133a	↓	PTMA, PNP		[60]
miR-133a/b	↓	EGFR, MMP-2		[92]
miR-133b	↓	Bcl-w, AKT1		[37]
miR-138	↓	ZEB2		[93]
miR-139-3p/5p	↓	MMP11		[94]
miR-143	↓	IGF-1R		[95]
miR-143/145 cluster	↓	PAI-1		[96]
miR-144	↓	EZH2	Wnt signaling/EZH2/Nkd1	[97]
miR-144-5p	↓	CCNE1/2, CDC25A		[31]
miR-145	↓	FSCN1		[98]
miR-145	↓	SOCS7	PI3K/AKT signaling	[99]
miR-145	↓	PAK1		[100]
miR-145	↓	IGF-IR		[101]
miR-145-3p/5p	↓	UHRF1		[102]
miR-146-3p	↓	PTTG1		[103]
miR-148a-3p	↓	ERBB3, DNMT1, AKT2		[104]
miR-1826	↓	VEGFC, CTNNB1, MAP2K1	MAPK-ERK signal transduction	[105]
miR-186	↓	NSBP1		[106]
miR-193-3p	↓	HOXC9	DNA damage response and oxidative stress	[107]
miR-194	↓	RAP2B		[108]
miR-195	↓	Cdk4	G1-phase arrest	[109]
miR-195	↓	Cdc42	Cdc42/STAT3 signaling	[110]
miR-195/497 cluster	↓	BIRC5, WNT7A		[21]
miR-199-3p/5p	↓	ITGA3		[111]
miR-199a-3p/5p	↓	ITGA3		[111]
miR-199a-5p	↓	MLK3	MLK3/IκB/NF-κB	[112]
miR-199a-5p	↓	CCR7	EMT	[35]
miR-200c	↓	BMI-1, E2F3	EMT	[113]
miR-203	↓	bcl-w		[114]
miR-203	↓	AKT2, Src	PI3K/AKT signaling	[115]
miR-205	↓	CCNJ		[116]
miR-206	↓	YRDC		[104]
miR-214	↓	PDRG1		[117]
miR-218	↓	LASP1		[57]
miR-218	↓	BMI-1	PI3K/AKT signaling	[118]
miR-218	↓	Glut1		[119]
miR-320c	↓	Cdk6	G1-phase arrest	[120]
miR-320s	↓	ITGB3		[121]
miR-335	↓	ROCK1		[122]
miR-335	↓	MAPK1		[38]
miR-409-3p	↓	c-Met		[123]
miR-429	↓	E-cad, ZEB1/2, β-catenin	EMT	[124]
miR-430	↓	CXCR3		[125]
miR-433	↓	CREB, c-Met	c-Met/AKT/GSK-3β/Snail signaling, EMT	[126]
miR-451	↓	c-Myc		[127]
miR-485-5p	↓	HMGA2	EMT	[128]
miR-490-5p	↓	c-FOS	G1-phase arrest	[129]
miR-490-5p	↓	c-FOS		[130]

AKT/PKB, Protein kinase B; PI3K-AKT, Phosphatidylinositol-4,5-bisphosphate 3-kinase-Protein kinase B; EMT, epithelial-mesenchymal transition; EGFR, Epidermal growth factor receptor; PPP2R2A, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; ↑, upregulated expression; ↓, downregulated expression.