NAFLD |
Nonalcoholic fatty liver disease |
NASH |
Nonalcoholic steatohepatitis |
TG |
Triglycerides |
DNL |
De novo lipogenesis |
VLDL |
Very low-density lipoproteins |
FFAs |
Free fatty acids |
PNPLA3 |
Patatin-like phospholipase domain-containing 3 |
SREBP |
Sterol regulatory element-binding protein |
LXR |
Liver X receptor |
RXR |
Retinoid X receptor |
TM6SF2 |
Transmembrane 6 superfamily member 2 |
GCKR |
Glucokinase regulator |
MBOAT7 |
Membrane bound O-acyltransferase domain-containing 7 |
PUFAs |
Polyunsaturated fatty acids |
SFAs |
Saturated fatty acids |
MUFAs |
Monounsaturated fatty acids |
PGC-1 |
PPAR-γ coactivator-1beta |
SCD1 |
Stearoyl-CoA desaturase-1 |
FAS |
Fatty acid synthase |
DGAT |
Diacylglycerol acyltransferase DGAT |
PPARs |
Peroxisome proliferator-activated receptors |
ChREBP |
Carbohydrate-Responsive Element-Binding Protein |
JNK |
c-Jun N-terminal kinases |
IRS-1 |
Insulin receptor substrate 1 |
Fe |
Iron |
Cu |
Copper |
Cdkn1a |
Cyclin-dependent kinase inhibitor 1a |
PCK1 |
Pyruvate carboxy kinase 1 gene |
MTTP |
Microsomal triglyceride transfer protein |
SIRT1 |
Sirtuin 1 |