Table 2.
Percentage of cells in G1 cell cycle phase after incubating with BI-9564 and I-BRD9 at the indicated concentrations for 72 h. (n ≥ 3; mean ± SD; * treatment vs. control with p < 0.05, one-way ANOVA).
| Treatment | Cell Line | |||
|---|---|---|---|---|
| BT12 | Chla266 | G401 | ||
| BI-9564 | C | 65.0 ± 3.9 | 74.1 ± 3.2 | 51.7 ± 2.0 |
| 5 µM | 73.1 ± 4.6 | 80.0 ± 1.8 | 57.6 ± 2.6 | |
| 10 µM | 74.0 ± 3.4 | 81.2 ± 1.8 * | 59.5 ± 3.6 * | |
| 20 µM | 78.9 ± 6.3 * | 83.6 ± 0.9 * | 65.5 ± 3.3 * | |
| I-BRD9 | C | 69.0 ± 1.9 | 74.2 ± 3.6 | 46.7 ± 1.9 |
| 5 µM | 75.0 ± 5.3 | 79.5 ± 3.2 | 53.0 ± 1.6 | |
| 10 µM | 80.1 ± 5.8 | 82.7 ± 2.9 * | 67.1 ± 9.1 * | |
| 20 µM | 85.6 ± 4.3 * | 89.3 ± 2.5 * | 78.1 ± 2.7 * | |