Table 4.
IC50 and combination indices (CI) of combined treatments. Treatment of BT12 and G401 with combinations of I-BRD9 and three cytotoxic drugs for 72 h. CI < 1 indicates synergistic effects and CI > 1 antagonistic effects of combined drugs. R2 represents the determination coefficient of linear regression in median effect plot. (n ≥ 3).
| Treatment | BT12 | G401 | ||||
|---|---|---|---|---|---|---|
| IC50 (µM) | CI | R2 | IC50 (µM) | CI | R2 | |
| Carboplatin + I-BRD9 | 40.9 | 1.01 | 0.83 | 9.1 | 0.37 | 0.94 |
| Doxorubicin + I-BRD9 | 0.94 | 0.42 | 0.94 | 0.096 | 1.2 | 0.84 |
| Vincristine + I-BRD9 | 16.7 | 96.1 | 0.59 | 0.008 | 9.0 | 0.88 |