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. 2017 Jul 21;18(7):1538. doi: 10.3390/ijms18071538

Figure 2.

Figure 2

Curative effect of PEG-HM-3 alone or in combination with Methotrexate (MTX) on adjuvant-induced arthritis rats. All parameters were evaluated once every three days from the 13th day to the 28th day after disease onset (day 13, 16, 19, 22, 25, 28). (A) Swelling of the left-hind paws (mL); (B) Swelling of the right-hind paws (mL); (C) Arthritis index; (D) Clinical score; (E) Weight added (g) at the 28th day. MTX (1 mg·kg−1), PEG-HM-3 (10 mg·kg−1) and combination of MTX (1 mg·kg−1) and PEG-HM-3 (10 mg·kg−1) were used. Values are means and standard error of the mean (SD) ((A–E), n = 9 in each group); (F) Morphology of the left- and right-hinds paws in each group; (G) X-ray exhibition of the left-hind paws of rats at the end of the experiment; (H) The radiographic analysis of the left-hind paws (n = 8 in each group). Versus AIA model group. ** p < 0.01; *** p < 0.001.