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. 2017 Jul 19;18(7):1571. doi: 10.3390/ijms18071571

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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All images are at 10× magnification with an insert at 25× magnification. (A) Positive control of ovarian cancer metastasis in the colon shows cystoplasmatic and membrane-associated staining; (B) Negative control of ovarian cancer metastasis in the colon; (C) Squamous cell carcinoma Immunoreactive score (IRS) 1; (D) Adenocarcinoma IRS 1; (E) Squamous cell carcinoma IRS 4; (F) Adenocarcinoma IRS 4; (G) Adenocarcinoma carcinoma IRS 8; (H) Squamous cell carcinoma IRS 8, (I) Squamous cell carcinoma IRS 9; (J) Prostaglandin E receptor type 3 (EP3) staining of an Fédération Internationale de Gynécologie et d’Obstétrique (FIGO) Ib diagnosed IRS 2 stained squamous cell carcinoma; (K) EP3 staining of an FIGO 4 diagnosed IRS 4 stained squamous cell carcinoma; (L) Boxplot of FIGO I and FIGO II–IV cases with median IRS.