Figure 1.

The levels of TSH, TPO AB, FT4, TG AB, and age measured in wild-type (GG), heterozygote (GA) and rare homozygote (AA) genotypes.

Notes: (A–E)rs180195 polymorphism in promoter of TG gene conceivably, regulates transcription activity of TG gene and possibly translation of TG protein – this effect can be manifested in levels of TSH, TPO, T4, TG, and age at the onset of disease. As reflection of function of TG, we measured levels of each of these parameters in wild-type, heterozygote, and rare homozygote genotypes. *Significant difference in TSH levels was observed between the wild-type and heterozygote genotype (A).

Abbreviations: AB, antibody; TSH, thyroid stimulating hormone; T4, tetraiodothyronine; FT4, free tetraiodothyronine.