Table 3.
Genotype of TG rs180195 SNP distribution in patients with autoimmune thyroid disease with and without ophthalmopathy and controls
| Patient group | Wild-type GG | Heterozygote GH | Homozygote AA | Total | MAF | χ2 | P-value |
|---|---|---|---|---|---|---|---|
| Number % | Number % | Number % | Number % | ||||
| GO | 35 (43) | 29 (35) | 18 (22) | 82 (100) | 40% | ||
| GH | 50 (32) | 75 (48) | 31 (20) | 156 (100) | 44% | ||
| HT | 39 (27) | 76 (53) | 28 (20) | 143 (100) | 46% | ||
| Control | 65 (44) | 58 (39) | 25 (17) | 148 (100) | 36% | ||
| Total | 189 (36) | 238 (45) | 102 (19) | 529 (100) | 13.36 | 0.038 |
Note: Number of patients expressed as % of each population.
Abbreviations: SNP, single nucleotide polymorphism; GO, Graves’ ophthalmopathy; GH, Graves’ hyperthyroidism; HT, Hashimoto’s thyroiditis; MAF, minor allele frequency.