Table 5.
Wild-type genotype of TG rs180195 SNP distribution in patients with autoimmune thyroid disease with and without ophthalmopathy, and controls
| Patient group | Wild-type GG | Variant GA + AA | χ2 | Odds ratio (95% confidence interval) | P-value |
|---|---|---|---|---|---|
| Number (%) | Number (%) | ||||
| GO | 35 (15) | 47 (20) | 2.65 | 1.60 | 0.104 |
| GH | 50 (21) | 106 (44) | (0.90–2.74) | ||
| GO | 35 (15) | 47 (21) | 0.033 | 0.95 | 0.856 |
| Control | 65 (28) | 83 (36) | (0.55–1.64) | ||
| GO | 35 (16) | 47 (21) | 5.61 | 1.99 | 0.018 |
| HT | 39 (17) | 104 (46) | (1.12–3.52) | ||
| GH | 50 (17) | 106 (35) | 4.55 | 0.60 | 0.033 |
| Control | 65 (21) | 83 (27) | (0.38–0.96) | ||
| HT | 39 (13) | 104 (36) | 8.77 | 0.48 | 0.003 |
| Control | 65 (22) | 83 (29) | (0.29–0.78) | ||
| GH | 50 (17) | 106 (35) | 0.82 | 1.26 | 0.367 |
| HT | 39 (13) | 104 (35) | (0.76–2.07) |
Notes: Number of patients expressed as % of total population of each pair. The significant P-values are highlighted in bold.
Abbreviations: SNP, single nucleotide polymorphism; GO, Graves’ ophthalmopathy; GH, Graves’ hyperthyroidism; HT, Hashimoto’s thyroiditis.