Table 6.
Heterozygous genotype of TG rs180195 SNP distribution in patients with autoimmune thyroid disease with and without ophthalmopathy, and controls
| Patient group | Heterozygote GA | Variant GG + AA | χ2 | Odds ratio (95% confidence interval) | P-value |
|---|---|---|---|---|---|
| Number (%) | Number (%) | ||||
| GO | 29 (12) | 53 (22) | 3.53 | 0.59 | 0.060 |
| GH | 75 (32) | 81 (34) | (0.34–1.02) | ||
| GO | 29 (12) | 58 (25) | 0.81 | 0.78 | 0.369 |
| Control | 58 (25) | 90 (38) | (0.44–1.35) | ||
| GO | 29 (13) | 53 (23) | 6.62 | 0.48 | 0.010 |
| HT | 76 (34) | 67 (30) | (0.27–0.84) | ||
| GH | 75 (25) | 81 (26) | 2.44 | 1.44 | 0.118 |
| Control | 58 (19) | 90 (30) | (0.91–2.27) | ||
| HT | 76 (26) | 67 (23) | 5.70 | 1.76 | 0.017 |
| Control | 58 (20) | 90 (31) | (1.10–2.80) | ||
| GH | 75 (25) | 81 (27) | 0.77 | 0.82 | 0.381 |
| HT | 76 (26) | 67 (22) | (0.52–1.29) |
Notes: P=<0.1 indicates a tendency toward significance. Number of patients expressed as % of total population of each pair. The significant P-values are highlighted in bold.
Abbreviations: SNP, single nucleotide polymorphism; GO, Graves’ ophthalmopathy; GH, Graves’ hyperthyroidism; HT, Hashimoto’s thyroiditis.