Table 7.
Homozygous genotype of TG rs180195 SNP distribution in patients with autoimmune thyroid disease with and without ophthalmopathy, and controls
| Patient group | Homozygote AA | Variant GG + GA | χ2 | Odds ratio (95% confidence interval) | P-value |
|---|---|---|---|---|---|
| Number (%) | Number (%) | ||||
| GO | 18 (7) | 64 (27) | 0.14 | 1.134 | 0.706 |
| GH | 31 (13) | 125 (53) | (0.59–2.18) | ||
| GO | 18 (8) | 64 (28) | 0.89 | 1.38 | 0.346 |
| Control | 25 (11) | 123 (53) | (0.75–2.72) | ||
| GO | 18 (8) | 64 (28) | 0.18 | 1.15 | 0.671 |
| HT | 28 (13) | 115 (51) | (0.59–2.25) | ||
| GH | 31 (10) | 125 (41) | 0.45 | 1.22 | 0.501 |
| Control | 25 (8) | 123 (41) | (0.68–2.18) | ||
| HT | 28 (10) | 115 (39) | 0.35 | 1.20 | 0.552 |
| Control | 25 (9) | 123 (42) | (0.66–2.17) | ||
| GH | 31 (10) | 125 (42) | 0.004 | 1.02 | 0.950 |
| HT | 28 (9) | 115 (39) | (0.58–1.80) |
Notes: P=<0.1 indicates a tendency toward significance. Number of patients expressed as % of total population of each pair.
Abbreviations: SNP, single nucleotide polymorphism; GO, Graves’ ophthalmopathy; GH, Graves’ hyperthyroidism; HT, Hashimoto’s thyroiditis.