Actin |
modulation of clot structure and properties (Talens et al. 2012) |
Albumin |
modulation of lateral aggregation and clot structure (Galanakis et al. 1987; Talens et al. 2012) |
α1-Antitrypsin |
local regulation of proteases involved in coagulation or fibrinolysis (Talens et al. 2012) |
α2-Antiplasmin |
local regulation of fibrinolysis (Tsurupa et al. 2010) |
Apolipoproteins A-IV, A-I, J, E |
associated with high-density lipoproteins; the physio logic role of binding to fibrin(ogen) is not clear (Talens et al. 2012) |
Carboxypeptidase N |
a local fibrinolysis inhibitor (Talens et al. 2012) |
CD44 |
mediates tumor metastasis at the sites of fibrin deposition (Alves et al. 2009) |
Coagulation Factor Xa |
a negative feedback for thrombin generation (Iino et al. 1995) |
Coagulation Factor VIII |
platelet-attached soluble fibrin mediates binding of Factor VIII (Gilbert et al. 2015) |
Coagulation Factor XIII |
crosslinking of fibrin and multiple plasma proteins (Weisel and Dempfle 2013) |
Complement C3 |
delayed fibrinolysis (Howes et al. 2012) |
Factor H-related proteins-associated lipoprotein particles (FALP) |
the physiologic role of fibrinogen on FALP is not clear (Park and Wright 2000) |
Ferritin |
some fibrinogens circulate in the form of a complex with ferritin (Takahashi et al. 2013) |
Fibroblast Growth Factor-2 |
augmented angiogenesis and cell proliferation at the sites of fibrin deposition (Sahni et al. 1999) |
Fibulin |
interferes with the fibrin assembly (Tran et al. 1995) |
Haptoglobin |
associated with high-density lipoproteins; the physiologic role of binding to fibrin(ogen) is not clear (Talens et al. 2012) |
Hepatocyte-derived fibrinogen related protein-1 |
liver cell growth regulation (Talens et al. 2012) |
Immunoglobulins |
modulate fibrin structure, localize immune and inflam matory reactions (Talens et al. 2012) |
Interleukin-1β |
modulation of inflammation (Sahni et al. 2004) |
Lipoprotein(a) |
modulation of fibrinolysis (Weisel and Litvinov 2014) |
α2-Macroglobulin |
local regulation of proteases involved in coagulation or fibrinolysis (Talens et al. 2012) |
Myosin |
modulation of fibrinolysis (Kolev et al. 2003) |
Plasma fibronectin |
platelet adhesion and thrombus formation (Gailit and Ruoslahti 1988; Talens et al. 2012) |
Plasminogen |
promotion of fibrinolysis (Weisel and Litvinov 2014) |
Plasminogen activator inhibitor-1 |
modulation of fibrinolysis (Smolarczyk et al. 2005) |
Serum amyloid P |
associated with high-density lipoproteins; the physiologic role of binding to fibrin(ogen) is not clear (Talens et al. 2012) |
Thrombin |
elimination of active thrombin from the circulation (Weisel and Dempfle 2013) |
Thrombin-activatable fibrinolysis inhibitor (TAFI) |
modulation of fibrinolysis (Valnickova and Enghild 1998) |
Thrombospondin |
modulation of fibrinolysis (Bacon-Baguley et al. 1990) |
Tissue-type plasminogen activator (t-PA) |
promotion of fibrinolysis (Medved et al. 2001) |
Vascular Endothelial Growth Factor (VEGF) |
promotion of angiogenesis at the sites of fibrin deposition (Sahni and Francis 2000) |
VE-cadherin |
suppression of inflammation by inhibiting leukocyte transmigration at the sites of fibrin deposition (Yakovlev et al. 2011) |
Very low density lipoprotein receptor (VLDLR) |
promotion of inflammation and transendothelial migration of leukocytes at the sites of fibrin deposition (Yakovlev and Medved 2015) |
Vitronectin |
platelet adhesion and thrombus formation (Schvartz et al. 2002; Podor et al. 2002) |
von Willebrand Factor |
platelet adhesion and thrombus formation (Miszta et al. 2014) |