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. 2017 Jul 31;8:918. doi: 10.3389/fimmu.2017.00918

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Copyright © 2017 Sharma, Cinti and Capobianco.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Composite targets in Ip. (A) Network configuration. (B) Identified sub-complexes. (C) TOP eigenvector component values corresponding to interacting seed proteins for the top-5 eigenvalues. The first eigenvector values refer to principal eigenvalues. Red dots denote critical nodes in first order PPIN networks and violet circles denote proteins participating in complexes. Notes: miR-140-5p regulates a critical node, ALDH1A1 and is classified as a critical link; critical nodes KRT8, COL4A2, COL4A1, and PLAT interact with other non-critical nodes.

Composite targets in Ip. (A) Network configuration. (B) Identified sub-complexes. (C) TOP eigenvector component values corresponding to interacting seed proteins for the top-5 eigenvalues. The first eigenvector values refer to principal eigenvalues. Red dots denote critical nodes in first order PPIN networks and violet circles denote proteins participating in complexes. Notes: miR-140-5p regulates a critical node, ALDH1A1 and is classified as a critical link; critical nodes KRT8, COL4A2, COL4A1, and PLAT interact with other non-critical nodes.