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. 2017 Jul 31;8:918. doi: 10.3389/fimmu.2017.00918

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Copyright © 2017 Sharma, Cinti and Capobianco.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Controllability analysis. Top panel: gene–gene co-expression networks, miRNA-gene target networks and protein–protein interaction (PPI)-miRNA interaction networks showing occurrence of critical, ordinary, and redundant nodes. Mid panel: Critical nodes in multi-layered networks mapped to first order networks. Bottom panel: critical nodes computed in PPI first order networks and number of critical nodes in protein complexes that are manually curated and experimentally validated in CORUM database. Further statistics on classification of nodes in various networks is provided in Figure 5.