Table 2.

Univariate and multivariate Cox regression analyses of recurrence-free survival^*

	Univariate		Multivariate
Characteristic	Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)	P value
Patient sex (M or F)	1.4 (0.89–2.18)	0.14	1.2 (0.76–1.9)	0.41
Age (>60 years or not)	0.88 (0.62–1.25)	0.49	0.85 (0.58–1.26)	0.43
AFP (>300 ng/ml or not)	1.25 (0.94–1.67)	0.12	1.02 (0.75–1.38)	0.9
Cirrhosis (yes or no)	1.08 (0.72–1.64)	0.68	1.18 (0.75–1.83)	0.45
Tumor size (>5 cm or not)	1.34 (1.0–1.79)	0.04	1.13 (0.82–1.56)	0.42
Cohort (Korean or FULCI)	1.17 (0.85–1.59)	0.32	1.16 (0.82–1.6)	0.38
BCLC stage (B/C/D or 0/A)	1.74 (1.2–2.3)	< 0.001	1.47 (1.05–2.1)	0.02
SOH signature (SOH or AH)	1.83 (1.31–2.5)	< 0.001	1.6 (1.14–2.39)	0.006

^*Patients in Korean and FULIC cohorts were only included for analysis.

CI, confidence interval

AFP, alpha-fetoprotein

BCLC, Barcelona Clinic Liver Cancer

SOH, silence of Hippo pathway

AH, active Hippo pathway

FULCI, Fudan University Liver Cancer Institute