Skip to main content
. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Neurobiol Aging. 2017 Apr 20;56:211.e1–211.e7. doi: 10.1016/j.neurobiolaging.2017.04.009

Table 2.

Association of common variants with cognitive performance

Test Gene Region Chr Position (hg19) SNP Type MAF N β SE P PFDR PFWE
HVLT-R TR PARP4 13 25068808 rs9318600 missense 0.10 1039 1.88 0.37 2.9 × 10−7 0.0059 0.014
MDM1 12 68720534 rs117673673 missense 0.01 1040 −3.62 0.71 3.7 × 10−7 0.0059 0.017
PARP4 13 25082630 rs9581094 intronic 0.15 1040 1.65 0.32 3.8 × 10−7 0.0059 0.018
HVLT-R DR ALS2CR11 2 202352480 rs72939119 missense 0.02 1038 1.66 0.31 5.7 × 10−8 0.0027 0.003
FAT3 11 92577659 rs75081660 missense 0.01 1038 2.07 0.43 1.4 × 10−6 0.032 0.06
TMT B-Aa RYR1 19 39018347 rs55876273 missense 0.02  867 −34.84 6.26 2.6 × 10−78 6.4 × 10−4 0.001
IFT140 16 1652418 rs146128830 missense 0.01  867 −37.05 6.67 2.7 × 10−08 6.4 × 10−4 0.001
MTCL1 18 8806925 rs34877994 missense 0.01  867 −41.13 8.27 6.7 × 10−7 0.0096 0.03
MOCS3 20 49576664 rs7269297 missense 0.01  867 −36.47 7.40 8.2 × 10−7 0.0096 0.04
Intergenic 9 97314741 rs16910061 intergenic 0.02  867 −28.13 6.07 3.6 × 10−6 0.034 0.17
RASAL3 19 15565646 rs56209154 missense 0.02  867 −29.23 6.46 6.0 × 10−6 0.047 0.28
JoLOb,c GBAd 1 155206167 rs2230288 missense 0.03  919 −143.61 25.16 1.2 × 10−8 2.7 × 10−4 2.8 × 10−4
ACSBG2 19 6141593 rs79266675 missense 0.02  919 159.86 29.67 7.1 × 10−8 8.3 × 10−4 0.003
Intergenic 9 8230433 rs1984216 intergenic 0.43  919 −44.12 9.66 4.9 × 10−6 0.033 0.23

Key: Chr, chromosome; HVLT-R, Hopkins Verbal Learning Test-Revised; DR, delayed recall; TR, total recall; JoLO, Benton Judgment of Line Orientation; MAF, minor allele frequency; MoCA, Montreal Cognitive Assessment; PFDR, false discovery rate-corrected P-value; PFWE, family wise error-corrected P-value; TMT, Trail Making Test.

a

Not administered at University of Pennsylvania

b

Not administered at University of California, Los Angeles

c

Based on square-transformed scores.

d

Not shown are results from four SNPs in neighboring genes (rs71628662 [ASH1L], rs12726330 [SLC50A1], rs71630614 [LMNA], rs34372695 [RAB25]) that were each highly correlated with GBA rs2230288 (see Supplementary Materials for details).