FIGURE 4.

Brain connectivity and virtual therapy on the virtual stoke patient brain. The upper row shows the effect of damage and the corresponding anatomical tracts. These scatter plots show a linear relationship between the percentage of damage in individual regions and the number of tracts associated with them (degree centrality). Two examples are shown. (a, precentral gyrus) The linear trend is clear for most cases. Some of them, however, showed a disproportionate reduction in the number of tracts despite the small percentage of lesion suggesting transneuronal degeneration originated in the large cortical strokes in these cases. (b, putamen) Note the clear linear trend seen in subcortical stroke. The lower row shows the process and effect of parameter normalization on brain dynamics. (c) Example of The Virtual Therapy implementation for one stroke case. Parameters were normalized from the baseline value to the healthy control average. (d) Frequency histogram showing the number of stroke cases stratified by percentage of change in the correlation of functional connectomes from baseline after The Virtual Therapy in relation to healthy controls. In all but three cases, the functional connectivity matrices after the therapy were closer to those in healthy controls. Changing the parameter values in the stroke patients to mimic those in controls resulted in healthier brain dynamics even when the damage did not change.