Extended Data Table 1. Overview of somatic point mutations detected in ASCs.

ASC	Donor	Age (years)	Gender	Tissue	Surveyed genome (%)*	No. point mutations†
1-a	1	9	Female	Colon	93.8	458
1-b	1	9	Female	Colon	91.2	400
1-c	1	9	Female	Colon	97.6	867
2-a	2	15	Male	Colon	96.8	923
2-b	2	15	Male	Colon	96.8	997
18-a	18	53	Male	Colon	98.5	2,468
18-b	18	53	Male	Colon	98.1	2,201
19-a	19	56	Male	Colon	97.7	2,655
19-b	19	56	Male	Colon	97.1	2,384
19-c	19	56	Male	Colon	98.2	3,383
19-d	19	56	Male	Colon	97.8	2,811
4-a	4	66	Female	Colon	90.7	2,140
4-b	4	66	Female	Colon	95.3	2,234
4-c	4	66	Female	Colon	95.7	2,332
4-d	4	66	Female	Colon	93.9	2,386
4-e	4	66	Female	Colon	96.1	2,289
3-a	3	67	Female	Colon	91.8	2,409
3-b	3	67	Female	Colon	91.8	2,882
3-c	3	67	Female	Colon	91.9	2,561
3-d	3	67	Female	Colon	92.0	2,667
3-e	3	67	Female	Colon	92.0	2,957
5-a	5	3	Female	Small intestine	89.0	246
5-b	5	3	Female	Small intestine	85.5	245
5-c	5	3	Female	Small intestine	88.5	304
6-a	6	8	Female	Small intestine	97.1	591
6-b	6	8	Female	Small intestine	93.5	506
6-c	6	8	Female	Small intestine	96.2	614
7-a	7	44	Male	Small intestine	91.1	1,461
8-a	8	45	Male	Small intestine	95.5	1,838
9-a	9	45	Male	Small intestine	93.9	1,571
10-a	10	70	Female	Small intestine	94.8	2,497
11-a	11	74	Male	Small intestine	87.3	2,613
12-a	12	78	Female	Small intestine	95.6	3,516
13-a	13	87	Male	Small intestine	97.7	3,512
13-b	13	87	Male	Small intestine	97.0	1,957
14-a	14	30	Male	Liver	81.3	771
14-b	14	30	Male	Liver	85.2	888
15-a	15	41	Female	Liver	93.5	1,292
15-b	15	41	Female	Liver	95.1	1,351
17-a	17	46	Female	Liver	79.4	1,495
17-b	17	46	Female	Liver	73.7	1,273
18-c	18	53	Male	Liver	97.9	1,845
18-d	18	53	Male	Liver	98.5	1,504
18-e	18	53	Male	Liver	98.2	1,577
16-a	16	55	Male	Liver	97.5	1,919

^*Percentage of the non-N autosomal genome with ≥20× coverage in both ASC culture and reference sample.

^†Number of somatic point mutations detected within surveyed genome.