Table 3. Subgroup analyses of heritability for six cancers.
| Cancer types | Subgroups | hL 1(SE) | P | P 2 |
|---|---|---|---|---|
| Lung cancer | Male | 0.153(0.023) | 1.61E-07 | 0.190 |
| Female | 0.243(0.062) | 4.73E-05 | ||
|
| ||||
| Smoker | 0.144(0.038) | 6.45E-05 | 0.165 | |
| Nonsmoker | 0.225(0.045) | 8.60E-08 | ||
|
| ||||
| Gastric Cancer | Male | 0.227(0.053) | 7.17E-06 | 0.421 |
| Female | 0.336(0.125) | 3.44E-04 | ||
|
| ||||
| Smoker | 0.192(0.088) | 1.34E-02 | 0.144 | |
| Nonsmoker | 0.347(0.059) | 8.00E-10 | ||
|
| ||||
| Drinker | 0.247(0.111) | 1.36E-02 | 0.805 | |
| Nondrinker | 0.278(0.054) | 6.97E-08 | ||
|
| ||||
| Hepatocellular carcinoma | Male | 0.088(0.043) | 1.80E-02 | 0.876 |
| Female | 0.059(0.180) | 3.67E-01 | ||
|
| ||||
| Smoker | 0.100(0.069) | 6.64E-02 | 0.727 | |
| Nonsmoker | 0.067(0.064) | 1.40E-01 | ||
|
| ||||
| Drinker | 0.000(0.090) | 5.00E-01 | 0.315 | |
| Nondrinker | 0.105(0.053) | 2.19E-02 | ||
|
| ||||
| Nasopharyngeal Cancer | Male | 0.158(0.042) | 1.05E-04 | 0.307 |
| Female | 0.084(0.059) | 8.55E-02 | ||
|
| ||||
| Esophageal squamous cell carcinoma | Male | 0.214(0.028) | 3.29E-14 | 0.917 |
| Female | 0.224(0.096) | 8.44E-04 | ||
|
| ||||
| Smoker | 0.187(0.036) | 1.22E-07 | 0.190 | |
| Nonsmoker | 0.272(0.053) | 2.95E-07 | ||
|
| ||||
| Drinker | 0.221(0.043) | 1.44E-07 | 0.315 | |
| Nondrinker | 0.159(0.044) | 1.04E-04 | ||
|
| ||||
| Breast Cancer | BMI ≤ 23.44 | 0.128(0.047) | 2.33E-03 | 0.734 |
| BMI > 23.44 | 0.106(0.047) | 1.29E-02 | ||
|
| ||||
| Age of menarche ≤ 14 | 0.048(0.048) | 1.63E-01 | 0.110 | |
| Age of menarche > 14 | 0.157(0.049) | 7.58E-04 | ||
1
Variance explained by all the autosomal SNPs in liability scale;
2
P value for genetic heterogeneity between subgroups.