Table 3.
Cancer outcomes for digital breast tomosynthesis in combination with digital mammography (DBT) compared to digital mammography (DM) alone
| Cancer outcomes‡ | DM* n=113,061 |
DBT* n=25,268 |
p-value | Unadjusted | Adjusted† | ||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | ||||
| Cancer rate per 1,000 | 4.9 | 6.5 | 0.0016 | 1.33 | (1.12–1.59) | 1.49 | (1.17–1.89) |
| Invasive cancer rate per 1,000 | 3.7 | 4.7 | 0.0252 | 1.27 | (1.04–1.56) | 1.45 | (1.09–1.92) |
| Total cancers (n) | 551 | 164 | |||||
| Invasive cancers (n) | 419 | 119 | |||||
| Ductal carcinoma in situ (n) | 132 | 45 | |||||
| Cancer detection rate per 1,000 | 4.4 | 5.9 | 0.0026 | 1.34 | (1.11–1.61) | 1.45 | (1.12–1.88) |
| Invasive cancer detection rate per 1,000 | 3.3 | 4.2 | 0.0449 | 1.26 | (1.01–1.56) | 1.38 | (1.02–1.87) |
| Total cancers (n) | 499 | 149 | |||||
| Invasive cancers (n) | 378 | 106 | |||||
| Ductal carcinoma in situ (n) | 121 | 43 | |||||
| False negative rate per 1,000 | 0.46 | 0.60 | 0.347 | 0.94 | (0.28–3.14) | 0.55 | (0.13–2.26) |
| PPV1 (cancers/recall), % | 4.1 | 6.4 | <0.0001 | 1.60 | (1.32–1.93) | 2.02 | (1.54–2.65) |
| Sensitivity % | 90.6 | 90.9 | 1.00 | 1.03 | (0.57–1.89) | 0.79 | (0.38–1.64) |
| Specificity % | 89.7 | 91.3 | <0.0001 | 1.22 | (1.16–1.28) | 1.39 | (1.30–1.48) |
*
Exams were restricted to women under observation for at least 1 year.
†
Adjusted for center, age (age 40–49, 50–59, 60–74), breast density (categories 1, 2, 3, 4), and first exam.
‡
Lobular cancer in situ is not included. Invasive or in situ behavior was unknown for one cancer diagnosis.