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. 2017 Apr 6;23(9):1179–1187. doi: 10.1177/1352458517703193

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© The Author(s), 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — An example of a treat-to-target algorithm, based on NEDA, for the treatment of patients with active MS.

Source: Reproduced with permission from Giovannoni et al.²

MRI: magnetic resonance activity; MS: multiple sclerosis; NABs: neutralizing antibodies; NEDA: no evident disease activity; Rx: treatment; IFNβ: interferon-beta.