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. 2017 Jul 31;12(7):e0178668. doi: 10.1371/journal.pone.0178668

Fig 3. Effect of cryotherapy on the time-course of arthritis.

Fig 3

AIA rats were treated or not (control) either by being placed into cages lined with ice pops for 30 minutes (n = 10) or by intermittent cold gas spray applications on hind paws for 2 minutes (n = 9), twice a day for 14 consecutive days from day 11 to day 24 post-immunization. Mean arthritis scores (A, C) and mean ankle diameter (B, D) were plotted over time after AIA induction. Results are expressed as means ± SEM (n = 9-10/group). 2-way ANOVAs on the whole 14 day treatment period were used and Bonferroni post-tests were performed at each evaluation time. ***p<0.001, **p<0.1, *p<0.05.