Table 2. Prior and concomitant medications used in those ertapenem-treated patients with or without development of seizures.
| Variables | Patients with seizures (33) | Patients without siezures(132) | p-value |
|---|---|---|---|
| Previous drug history within one month | 29 (87.9) | 98 (74.2) | 0.0961¥ |
| Calcium channel blocker | 15 (45.5) | 43 (32.6) | 0.1658¥ |
| ACEI or ARB | 4 (12.1) | 22 (16.7) | 0.5215¥ |
| Diuretics | 6 (18.2) | 26 (19.7) | 0.8439¥ |
| Beta blocker | 2 (6.1) | 15 (11.4) | 0.5286¥ |
| Alpha blocker | 1 (3.0) | 10 (7.6) | 0.6954¥ |
| Harnalidge | 4 (12.1) | 12 (9.1) | 0.5293¥ |
| Nitrate | 1 (3.0) | 10 (7.6) | 0.6954¥ |
| Statin | 3 (9.1) | 9 (6.8) | 0.7081¥ |
| Antibiotics | 7 (21.2) | 19 (14.4) | 0.3363¥ |
| H2-blocker | 9 (27.3) | 33 (25.0) | 0.7886¥ |
| Proton pump inhibitors | 4 (12.1) | 23 (17.4) | 0.4614¥ |
| Steroid | 3 (9.1) | 17 (12.9) | 0.7673¥ |
| Antiplatelet agents | 5 (15.2) | 31 (23.5) | 0.2999¥ |
| Prokinetic agents | 9 (27.3) | 29 (22.0) | 0.5175¥ |
| Drugs for peripheral vascular disorder | 3 (9.1) | 16 (12.1) | 0.7677¥ |
| Sedative/hypnotics | 2 (6.1) | 28 (21.2) | 0.0435¥ |
| Concomitant drugs with ertapenem | 33 (100.0) | 130 (98.5) | - |
| Proton pump inhibitors | 17 (51.5) | 52 (39.4) | 0.2067¥ |
| H2-blockers | 11 (33.3) | 49 (37.1) | 0.6858¥ |
| Prokinetic agents | 12 (36.4) | 41 (31.1) | 0.5595¥ |
| Harnalidge | 2 (6.1) | 15 (11.4) | 0.5286¥ |
| Albumin | 6 (18.2) | 27 (20.5) | 0.7703¥ |
| Opioids | 6 (18.2) | 32 (24.2) | 0.4595¥ |
| Non-steroid anti-inflammatory drug | 0 (0.0) | 9 (6.8) | 0.2067¥ |
| Steroid | 4 (12.1) | 41 (31.1) | 0.0289¥ |
| Inhaled bronchodilators | 14 (42.4) | 47 (35.6) | 0.4680¥ |
| Beta-blockers | 2 (6.1) | 18 (13.6) | 0.3711¥ |
| Diuretics | 10 (30.3) | 46 (34.9) | 0.6218¥ |
| Calcium channel blockers | 10 (30.3) | 51 (38.6) | 0.3751¥ |
| Statin | 2 (6.1) | 6 (4.6) | 0.6609¥ |
| Nitrate | 3 (9.1) | 10 (7.6) | 0.7249¥ |
| Cordarone | 1 (3.0) | 10 (7.6) | 0.6954¥ |
| Knowful | 4 (12.1) | 10 (7.6) | 0.4826¥ |
| Antiplatelet agents | 3 (9.1) | 28 (21.2) | 0.1108¥ |
| Drugs for peripheral vascular disorder | 2 (6.1) | 8 (6.1) | - |
| Transamine | 7 (21.2) | 18 (13.6) | 0.2776¥ |
| Sedative/hypnotics | 5 (15.2) | 25 (18.9) | 0.6138¥ |
| Antibiotics | 6 (18.2) | 32 (24.2) | 0.4595¥ |
| Contrast medium | 2 (6.1) | 20 (15.2) | 0.2529¥ |
¥ Chi-Square test.
ACEI: angiotensin converting enzyme inhibitor; ARB: angiotensin receptor blocker.