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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Biol Psychiatry. 2016 May 13;80(7):522–533. doi: 10.1016/j.biopsych.2016.04.023

Figure 3.

Figure 3

Striatal type 5 metabotropic glutamate receptor signaling increases and unbalances of striatal project neuron (SPN) output in Sapap3 knockout (KO) mice. Heat maps of direct SPN (dSPN; “X”) and indirect SPN (iSPN; “O”) event amplitudes (amp.) in the X–Y space showing representative responses to stimulation (Stim.) of cortical afferents (0.6 mA) in brain slices from Sapap3 KO mice treated with either (A) vehicle (Veh) or (B) MTEP. Summaries of (C) spike probability and (D) event amplitude demonstrate that MTEP decreases the SPN-evoked firing rate in Sapap3 KO mice. Summaries of dSPN/iSPN ratios for (E) spike probability and (F) event amplitude demonstrate that MTEP reverses the striatal pathway imbalance in Sapap3 KO mice. Veh: n= 313 dSPNs/205 iSPNs, 6 slices, 3 mice; MTEP: n= 384 dSPNs/284 iSPNs, 8 slices, 4 mice. Data are presented as means ± SEMs.