Table 3.
Decadal changes in aging and disease, Banner Sun Health Research Institute Brain and Body Donation Program/Arizona Study of Aging and Neurodegenerative Disorders.
| Decade (n) | Mean Control Brain Weight F/M | Mean Control MMSE (SD)a | Mean Control UPDRS III (SD)b | Mean Control CERAD NP Density (SD) | Mean Control Braak NFT Stage (SD) | % with Infarcts/Mean Total Infarct Volume, cc (SD)c | Mean Number of Neuropathological Diagnoses |
|---|---|---|---|---|---|---|---|
| 50s & 60s (112) | 1235d/1326 | NA | NA | 0.2 | 1.3 | 19/0.5 (2.4) | 2.4 |
| 70s (311) | 1141/1282 | 28.5 (1.3) | 3.9 (2.5) | 0.9 (1.1) | 2.3 (1.2) | 39/7.8 (41) | 2.8 (1.3) |
| 80s (595) | 1130/1257 | 28.0 (2.0) | 7.8 (7.2) | 1.3 (1.2) | 3.0 (1.0) | 49/10.7 (62) | 3.4 (1.4) |
| 90s (259) | 1110/1216 | 27.6 (1.9) | 11.2 (6.6) | 1.7 (1.2) | 3.6 (0.7) | 57/12.9 (55) | 3.9 (1.6) |
| 100s | 1069/NA | 25.5 (4.4) | 13.5 (10.4) | 1.4 (1.5) | 3.75 (0.5) | 92/5.5 (12) | 4.6 (1.3) |
a
MMSE score available for 24 (70s), 110 (80s), 69 (90s) and 4 (100s)
b
UPDRS score available for 17 (70s), 101 (80s), 71 (90s) and 4(100s).
c
Any number of acute, subacute or old infarcts were each counted as one diagnosis.
d
Based on n = 3 or less
CERAD=Consortium to Establish a Registry for Alzheimer’s Disease; F/M=Female/Male; MMSE=Minimental Status Exam; NA=not available; NFT=Neurofibrillary Tangle; NP=Neuritic Plaque; SD=Standard Deviation; UPDRS III=Unified Parkinson’s Disease Rating Scale III