Table 2.
Significant Regional Mean Volume Changes – Voxel-Based Morphometry (VBM)
| MNI Coordinates (x y z) | pFWE-corr | T | Region Description | ||
|---|---|---|---|---|---|
| Group x Time Interaction | |||||
| Healthy Controls vs. Combined Patient Group | |||||
| −32 | 21 | 55 | 0.070* | 4.47 | L Middle Frontal Gyrus |
| Healthy Controls vs. Chemotherapy Group | |||||
| −32 | 21 | 57 | 0.032* | 5.05 | L Middle Frontal Gyrus |
| Within Group – Time Effect | |||||
| Combined Patient Group (N=21) | |||||
| −30 | 12 | 58 | 0.008 | 7.62 | L Middle Frontal Gyrus |
| 34 | 14 | 51 | 0.048 | 6.56 | R Middle Frontal Gyrus |
| −3 | 12 | −2 | 0.030 | 6.85 | L Caudate |
| Chemotherapy Alone Group (N=16) | |||||
| −34 | 12 | 48 | 0.032 | 8.09 | L Middle Frontal Gyrus |
*
Middle Frontal Gyrus (bMFG) Small Volume Corrected
MNI=Montreal Neurological Institute; FWE-corr=family-wise error corrected.