Table 2. Association between race/ethnicity and fibroid presence by categories of BMI in the Vanderbilt University SD and CARDIA.
| Synthetic Derivative | CARDIA | Meta-analysis | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BMI Categories | N Cases/ Controls | ORa | (95% CI) | Pb | P-intc | N Cases/ Controls | ORa | (95% CI) | Pb | P-intc | OR | (95% CI) |
| <25kg/m2 | 846/3,728 | 0.52 | (0.43, 0.64) | <0.001 | 0.01 | 144/182 | 0.18 | (0.10, 0.32) | <0.001 | 0.75 | 0.47 | (0.39, 0.56) |
| 25–30 kg/m2 | 1,048/3,318 | 0.47 | (0.39, 0.56) | <0.001 | 179/99 | 0.25 | (0.14, 0.43) | <0.001 | 0.44 | (0.37, 0.53) | ||
| 30–35 kg/m2 | 867/2,360 | 0.36 | (0.30, 0.43) | <0.001 | 128/80 | 0.36 | (0.18, 0.71) | 0.003 | 0.36 | (0.30, 0.43) | ||
| >35 kg/m2 | 1,244/2,949 | 0.50 | (0.43, 0.58) | <0.001 | 156/85 | 0.35 | (0.19, 0.66) | 0.001 | 0.49 | (0.42, 0.57) | ||
aOR: whites (comparison group), blacks (reference group)
bP: p-value from z-score for individual categories
cP-int: p-value for global interaction using likelihood ratio test fitting a reduced and a full model.
Reduced model: logit(Fibroids) ~ BMI-category-0 (<25kg/m2: Reference) + BMI-category1 (25–30 kg/m2) + BMI-category2 (30–35 kg/m2) + BMI-category3 (>35 kg/m2) + race (African (0) or European (1)) + Age.
Full Model: logit(Fibroids) ~ BMI-category-0 (<25kg/m2: Reference) + BMI-category1 (25–30 kg/m2) + BMI-category2 (30–35 kg/m2) + BMI-category3 (>35 kg/m2) + race (African (0) or European (1)) + BMI-category1 x race + BMI-category2 x race + BMI-category3 x race + Age.