Table 5. Summary of empirically inferred local ancestry x BMI interaction analyses at top chromosome 2q31-32 SNP rs12999125: Continuous and stratified by BMI categories.
| BioVU | CARDIA | Meta | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P | OR | 95% CI | P | OR | SE | HetP | P | Direction | I2 | |
| *BMI x rs12999125 | 1.04 | 1.02–1.07 | 1.46x10-3 | 1.05 | 1.00–1.11 | 0.063 | 1.04 | 0.01 | 0.772 | 2.29x10-4 | ++ | 0% |
| BMI Category | ||||||||||||
| Overall | 0.89 | 0.70–1.13 | 0.328 | 1.08 | 0.69–1.77 | 0.728 | 0.93 | 0.11 | 0.447 | 0.480 | -+ | 0% |
| <25kg/m2 | 0.54 | 0.27–1.09 | 0.083 | 0.58 | 0.15–2.30 | 0.438 | 0.55 | 0.32 | 0.923 | 0.058 | -- | 0% |
| 25–30 kg/m2 | 0.60 | 0.37–0.97 | 0.037 | 1.81 | 0.68–4.86 | 0.238 | 0.74 | 0.22 | 0.048 | 0.176 | -+ | 74% |
| >30 kg/m2 | 1.25 | 0.90–1.73 | 0.186 | 1.04 | 0.53–2.03 | 0.916 | 1.20 | 0.15 | 0.628 | 0.216 | ++ | 0% |
OR = odds ratio; 95% CI = 95% confidence interval; Meta = Meta-analysis of two studies using inverse variance fixed effects model
BMI x rs12999125: refers to interaction odds ratio obtained from logistic regression model where logit(Fibroids) ~ local ancestry at rs12999125 (0, 1 or 2 European ancestry copies) + BMI (continuous) + BMI x local ancestry at rs12999125 + age + 10 principal components;
BMI category: refers to association between local ancestry at that marker and uterine fibroids without considering interaction with BMI across all individuals (overall), and among individuals with BMI <25 kg/m2, 25–30 kg/m2 or >30kg/m2
*Relevant estimates form the interaction model including those for BMI, local ancestry at rs6457825, and interaction of BMI x local ancestry at rs6457825 for BioVU and CARDIA are presented in S4 Table