Table 6. Summary of strongest SNP (rs71430182) association from BMI category and SNP interactions from 2q31-32.
| BIOVU AA | CARDIA AA | BIOVU EA (Replication) | Meta-analysis AA + EA | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Interaction Type | OR | SE | P | OR | SE | P | OR | SE | P | OR | P | I2 |
| BMI categories (0, 1, 2) x SNP a | 1.40 | 0.12 | 5.24x10-3 | 1.26 | 0.23 | 3.08x10-1 | 1.22 | 0.11 | 7.56x10-2 | 1.29 | 7.75x10-4 | 0 |
| BMI (continuous) x SNP | 1.02 | 0.01 | 3.44x10-2 | 1.04 | 0.02 | 4.98x10-2 | 1.04 | 0.01 | 3.74x10-3 | 1.03 | 7.15x10-5 | 0 |
| BMI(per SD) x SNP b | 1.22 | 0.09 | 3.49x10-2 | 1.39 | 0.17 | 4.99x10-2 | 1.32 | 0.09 | 3.85x10-3 | 1.28 | 5.80x10-5 | 0 |
| BMI Category | ||||||||||||
| < 25 kg/m2 | 0.73 | 0.17 | 6.43x10-2 | - | - | - | 0.74 | 0.16 | 5.19x10-2 | 0.73 | 7.30x10-3 | 0 |
| 25–30 kg/m2 | 0.83 | 0.15 | 2.02x10-1 | 0.89 | 0.30 | 6.91x10-1 | 0.97 | 0.18 | 8.60x10-1 | 0.88 | 2.39x10-1 | 0 |
| > 30 kg/m2 | 1.13 | 0.10 | 2.42x10-1 | 0.99 | 0.21 | 9.58x10-1 | 1.08 | 0.16 | 6.40x10-1 | 1.10 | 2.50x10-1 | 0 |
Effect allele (EA)/Reference allele (RA): G/A; Effect allele frequency in AFR (1000G): 0.61; Effect allele frequency in EUR (1000G): 0.86
a. Interaction was modeled between BMI-categories (0 = < 25 kg/m2; 1 = 25–30 kg/m2; 2 = > 30 kg/m2) and SNP, OR for this term represents the change in odds ratio for SNP in relation to fibroids across each category of BMI.
b. Interaction was modeled between standardized BMI (centered and divided by standard deviation) x SNP, OR for this term represents the change in odds ratio for SNP in relation to fibroids across each standard deviation increase in BMI
BMI Category: refers to associations between genetic variant and uterine fibroids among individuals with BMI <25 kg/m2, 25–30 kg/m2 or >30kg/m2