Table 1.

Inhibition of cell proliferation in the human hypopharyngeal carcinoma cell line FaDu, treated with metformin (25–125 mmol/l) for 12 h, 24 h and 36 h, relative to untreated control cultures (%).

Timepoint	Metformin concentration (mmol/l)
	0	25	50	75	100	125
12 h	0.0a	10.8 ± 7.8	17.0 ± 6.7b	35.4 ± 10.4c	45.5 ± 14.5d	45.7 ± 9.8
24 h	0.0a	14.4 ± 5.1	21.3 ± 7.4b	49.3 ± 7.1c	65.2 ± 12.4d	66.5 ± 6.7
36 h	0.0a	18.4 ± 7.6	25.7 ± 5.7b	57.6 ± 10.3c	72.9 ± 11.3d	74.0 ± 7.9

Data presented as mean ± SD (n = 3 for each experimental group)

^aP < 0.05 vs all other concentrations at same timepoint; ^bP < 0.05 vs 25 mmol/l metformin at same timepoint; ^cP < 0.05 vs 50 mmol/l metformin at same timepoint; ^dP < 0.05 vs 75 mmol/l metformin at same timepoint; one-way analysis of variance and Student–Newman–Keuls q-test.