Table 3.
Stratified analyses of the association between obstructive sleep apnoea (OSA) risk and the apolipoprotein gene (APOE) ɛ4 allele.
| Subgroups | Studies, n |
n
|
OR | 95% CI | Heterogeneity | |
|---|---|---|---|---|---|---|
| Patients | Controls | |||||
| Study design | ||||||
| Prospective | 10 | 1930 | 6544 | 1.02 | 0.82, 1.28 | I2 = 62.9% |
| Retrospective | 9 | 1268 | 1710 | 1.33 | 0.86, 2.05 | I2 = 80.0% |
| Source of controls | ||||||
| Population-based | 13 | 2498 | 7614 | 1.20 | 0.93,1.55 | I2 = 77.7% |
| Hospital-based | 6 | 700 | 640 | 0.64, 1.38 | I2 = 48.7% | |
| AHI cut off | ||||||
| >5–<15 | 3 | 577 | 1299 | 0.88 | 0.64, 1.02 | I2 = 0.0% |
| ≥15 | 10 | 1825 | 5719 | 0.99 | 0.79, 1.24 | I2 = 62.1% |
| ≥5 | 4 | 467 | 905 | 2.82 | 0.84, 9.45 | I2 = 88.9% |
| Total sample size | ||||||
| <500 | 11 | 1090 | 1063 | 1.45 | 0.91, 2.31 | I2 = 75.9% |
| ≥500 | 8 | 2108 | 7191 | 1.00 | 0.81, 1.22 | I2 = 68.8% |
| Chinese subjects | 2 | 134 | 146 | 5.87 | 3.13, 11.00 | I2 = 0.0% |
OR, odds ratio; CI, confidence interval; AHI, apnoea–hypopnea index.