Table 3.
Pain Satisfaction Scale at week 6 in patients with osteoarthritis of the knee who were treated with either 200 mg celecoxib once daily, 800 mg ibuprofen three times daily or placebo – pairwise comparison with placebo (MITT).
| Items | Celecoxib 200 mg once daily n = 148 | Ibuprofen 800 mg three times daily n = 150 | Placebo n = 77 | Statistical significancea |
||
|---|---|---|---|---|---|---|
| Celecoxib versus ibuprofen | Ibuprofen versus placebo | Celecoxib versus placebo | ||||
| 1. Happy with the duration of pain relief | 103 (69.6) | 99 (66.0) | 33 (42.9) | NS | P = 0.003 | P < 0.001 |
| 2. Relieves my pain quickly enough | 95 (64.2) | 89 (59.3) | 31 (40.3) | NS | P = 0.015 | P = 0.002 |
| 3. Has a positive effect on my physical health | 101 (68.2) | 93 (62.0) | 38 (49.4) | NS | NS | P = 0.018 |
| 4. Helps me have a better outlook on life | 92 (62.2) | 87 (58.4)b | 34 (44.2) | NS | NS | P = 0.025 |
| 5. Allows me to perform my daily activities more easily | 105 (70.9) | 93 (62.0) | 40 (51.9) | P = 0.033 | NS | P = 0.011 |
| 6. Allows me to perform my leisure activities more often | 105 (70.9) | 90 (60.0) | 35 (45.5) | P = 0.020 | NS | P < 0.001 |
| 7. Helps me do things independently | 99 (66.9) | 92 (61.7)b | 37 (48.1) | NS | NS | P = 0.010 |
| 8. Allows me to have better relationships with others | 88 (59.5) | 82 (55.0)b | 32 (41.6) | NS | NS | P = 0.026 |
| 9. Improves my mood | 95 (64.2) | 90 (60.0) | 34 (44.2) | NS | P = 0.036 | P = 0.010 |
| 10. Allows me to concentrate better | 80 (54.1) | 84 (56.0) | 35 (45.5) | NS | NS | NS |
| 11. Allows me to move around more easily | 108 (73.0) | 98 (65.8)b | 41 (53.2) | NS | NS | P = 0.007 |
Data presented as n of patients (%).
a
Significance assessed using a general linear model with treatment and centre as fixed effects, and baseline WOMAC scores as a covariate.
b
Data available for 149 patients.
MITT, modified intent-to-treat; NS, no statistically significant between-group differences (P ≥ 0.05).