Table 1.
Demographic and clinical characteristics of patients with systemic inflammatory response syndrome (SIRS) or sepsis included in a study evaluating the value of micro RNA-143 (miR-143) in sepsis diagnosis and prognosis.
| Characteristic | SIRS group n = 95 | Sepsis group n = 103 | Control group n = 40 |
|---|---|---|---|
| Sex, male/female | 65/30 | 71/32 | 22/18 |
| Age, years | 59.6 ± 10.2 | 58.1 ± 11.5 | 58.8 ± 10.7 |
| Cause of disease | |||
| Pulmonary infection | 0 | 17 | – |
| Post-surgery | 48 | 43 | – |
| Acute pancreatitis | 0 | 3 | – |
| Multiple trauma | 25 | 21 | – |
| Other | 22 | 19 | – |
| SOFA score20 | – | 6.1 ± 3.2 | – |
| APACHE II score21 | – | 15.9 ± 6.2 | – |
| CRP, mg/dl | 4.1 (0.3–6.7) | 13.9 (1.9–19.7)a | – |
| PCT, ng/ml | 0.71 (0.06–29.38) | 3.86 (0.35–139.73)a | – |
| ICU stay, days | 4 (1–29) | 10 (1–65)a | – |
| Survival/death | 81/14 | 65/38 | – |
| miR-143 relative expressiond | 11.5 ± 4.1b | 19.3 ± 5.6bc | 6.2 ± 2.0 |
Data presented as n, mean ± SD, or median (range).
a
P < 0.01 vs SIRS, bP < 0.01 vs control, cP < 0.001 vs SIRS; unpaired Student’s t-test.
d
Relative to U6 mRNA expression.
CRP, C-reactive protein; PCT, procalcitonin; ICU, intensive care unit.