Table 3.
Distribution of ECE1 gene polymorphism genotypes and their associations with risks of intracerebral haemorrhage (ICH) in patients with ICH and healthy control subjects.
| Polymorphism | Genotypes | Patients with ICH n = 389 | Control subjects n = 404 | Statistical significancea | Adjusted ORb (95% CI) |
|---|---|---|---|---|---|
| rs212528 | AA | 265 (68.1) | 258 (63.9) | 1.00 (reference) | |
| AG | 110 (28.3) | 128 (31.7) | NS | 1.361 (0.374, 4.362) | |
| GG | 14 (3.6) | 18 (4.5) | NS | 1.173 (0.301, 3.687) | |
| A allele | 640 (82.3) | 644 (79.7) | NS | ||
| G allele | 138 (17.7) | 164 (20.3) | |||
| rs213045 | GG | 118 (30.3) | 145 (35.9) | 1.00 (reference) | |
| GT | 200 (51.4) | 184 (45.5) | NS | 0.915 (0.432, 1.746) | |
| TT | 71 (18.3) | 75 (18.6) | NS | 1.259 (0.594, 2.361) | |
| G allele | 436 (56.0) | 474 (58.7) | NS | ||
| T allele | 342 (44.0) | 334 (41.3) |
Data presented as n of patients (%) or n of alleles (%).
a
Two-sided χ2-test test for distribution between the patients and control subjects.
b
Adjusted for age, sex, ischaemic heart disease, hypertension, type 2 diabetes mellitus, smoking and alcohol drinking status, systolic blood pressure, diastolic blood pressure, and fasting blood glucose in the binary logistic regression analysis.
OR, odds ratio; CI, confidence interval; NS, no statistically significant difference (P ≥ 0.05).