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. 2016 Apr 8;44(3):569–584. doi: 10.1177/0300060515597931

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© The Author(s) 2016

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Effects of hydroxysafflor yellow A (HSYA) treatment on monocrotaline (MCT)-induced pulmonary arterial hypertension-related pulmonary vascular remodelling in rats, showing: (A–D) representative photomicrographs of haematoxylin and eosin stained pulmonary arterioles in (A) control group, (B) MCT group, (C) MCT + HSYA group and (D) control + HSYA group; (E) HSYA attenuated the MCT-induced increase in pulmonary arteriole wall thickness; and (F) HSYA attenuated MCT-induced vascular muscularization in PAH by increasing nonmuscularization and decreasing full muscularization. Nonmuscularization, arterioles not occluded; Partial muscularization, arterioles not fully occluded; Full muscularization, arterioles fully occluded. Data presented as mean ± SD; magnification × 400; scale bars = 50 µm; *P < 0.05 versus control group; ^#P < 0.05 versus MCT group (one-way analysis of variance or χ²-test)

Figure 2. — Effects of hydroxysafflor yellow A (HSYA) treatment on monocrotaline (MCT)-induced pulmonary arterial hypertension-related pulmonary vascular remodelling in rats, showing: (A–D) representative photomicrographs of haematoxylin and eosin stained pulmonary arterioles in (A) control group, (B) MCT group, (C) MCT + HSYA group and (D) control + HSYA group; (E) HSYA attenuated the MCT-induced increase in pulmonary arteriole wall thickness; and (F) HSYA attenuated MCT-induced vascular muscularization in PAH by increasing nonmuscularization and decreasing full muscularization. Nonmuscularization, arterioles not occluded; Partial muscularization, arterioles not fully occluded; Full muscularization, arterioles fully occluded. Data presented as mean ± SD; magnification × 400; scale bars = 50 µm; *P < 0.05 versus control group; ^#P < 0.05 versus MCT group (one-way analysis of variance or χ²-test)