Figure 1.

T₂ maps of coronal brain slices depicting the regions-of-interest (ROIs). (a) Lesioned tissue was indentified by elevated T₂ values (left image). Total lesion volume (red and yellow ROIs combined) was calculated from ipsilateral tissue voxels with T₂ values 2SD above the mean of values in contralateral grey matter (superimposed on normalized T₂ maps) (right image). Subsequent automated image processing (i.e. erosion and dilation) generated three ROIs: lesion core (red), intralesional borderzone (yellow) and extralesional borderzone (blue). A contralateral ROI (green) encompassing cortical and subcortical tissue was manually selected. (b) Ipsi- (red) and contralateral ROIs (green) of the VPN (left image) and SN (right image) were manually outlined on posterior slices.