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. 2016 Jan 1;37(8):2780–2794. doi: 10.1177/0271678X16675368

Figure 5.

Figure 5.

Ischemic stroke selectively triggers upregulation of Cab39 protein expression in SHR brains. (a) SHR brain membrane fractions exhibit greater Cab39 protein abundance than do WKY brain membrane fractions. Ischemic stroke increases Cab39 levels in SHR cytosol fractions to a greater degree than in WKY brain cytosol fractions at 6-h reperfusion post-tMCAO. At 24-h reperfusion post-tMCAO, Cab39 expression was further increased in both membrane and cytosolic fractions in SHR brain. Data are mean ± SD, n = 4, *p < 0.05. (b) Immunofluorescence analysis showing Cab39 upregulation in peri-infarct cortex of SHR brain at 6-h post-tMCAO. Data are mean ± SD, n = 3, *p < 0.05. (c) Increased levels of WNK1, WNK4, and Cab39 proteins were detected in anti-tNKCC1 immunoprecipitates from ischemic IL cerebral cortices of SHR at 6-h reperfusion post-tMCAO compared with CL cortex of WKY. Data are mean ± SD, n = 4, *p < 0.05.