Table 3.
Associations of Individual Characteristics and Lifestyle Factors with MEHP:MEHHP and %MEHP (Regression Estimates and 95% Confidence Intervals), Participants without Prescription Medication Use in the Past Month, NHANES 2001–2012.
MEHP:MEHHP | log(%MEHP) | |||||||
---|---|---|---|---|---|---|---|---|
|
||||||||
Characteristic | Model 1a | Model 2b | Model 1a | Model 2b | ||||
|
||||||||
β | 95% CI | β | 95% CI | β | 95% CI | β | 95% CI | |
Age, years | ||||||||
Estimates | −0.001 | −0.002, 0.001 | −0.001 | −0.002, 0.001 | −0.004 | −0.006, −0.002 | −0.006 | −0.008, −0.003 |
Race | ||||||||
Caucasian | 0.000 | Reference | 0.000 | Reference | 0.000 | Reference | 0.000 | Reference |
Other Race | 0.028 | −0.018, 0.073 | 0.017 | −0.032, 0.066 | 0.172 | 0.046, 0.299 | 0.170 | 0.037, 0.302 |
Mexican-American or other | 0.010 | −0.021, 0.040 | 0.003 | −0.033, 0.038 | 0.137 | 0.060, 0.214 | 0.135 | 0.049, 0.220 |
Hispanic Non-Hispanic Black | 0.004 | −0.038, 0.046 | −0.008 | −0.055, 0.038 | 0.134 | 0.059, 0.209 | 0.128 | 0.038, 0.218 |
Gender | ||||||||
Male | 0.000 | Reference | 0.000 | Reference | 0.000 | Reference | 0.000 | Reference |
Female | 0.015 | −0.14, 0.045 | 0.014 | −0.015, 0.043 | −0.001 | −0.078, 0.077 | 0.009 | −0.070, 0.088 |
BMI | ||||||||
Normal | 0.000 | Reference | 0.000 | Reference | 0.000 | Reference | 0.000 | Reference |
Underweight | −0.005 | −0.095, 0.085 | 0.006 | −0.087, 0.098 | −0.051 | −0.214, 0.112 | −0.015 | −0.203, 0.172 |
Overweight | −0.039 | −0.068, −0.009 | −0.039 | −0.069, −0.009 | −0.103 | −0.164, −0.041 | −0.103 | −0.164,−0.042 |
Smoking | ||||||||
Never smoker | 0.000 | Reference | 0.000 | Reference | 0.000 | Reference | 0.000 | Reference |
Past smoker | −0.016 | −0.042, 0.011 | −0.011 | −0.036, 0.015 | 0.009 | −0.097, 0.116 | 0.007 | −0.108, 0.122 |
Current smoker | 0.022 | −0.004, 0.048 | 0.028 | −0.001, 0.057 | 0.105 | 0.023, 0.188 | 0.114 | 0.033, 0.195 |
Alcohol use | ||||||||
None | 0.000 | Reference | 0.000 | Reference | 0.000 | Reference | 0.000 | Reference |
Below limit | −0.004 | −0.032, 0.023 | −0.004 | −0.033, 0.025 | −0.063 | −0.174, 0.049 | −0.048 | −0.157, 0.062 |
Above limit | −0.022 | −0.060, 0.016 | −0.027 | −0.065, 0.011 | −0.112 | −0.243, 0.020 | −0.125 | −0.256, 0.005 |
Cancer history | ||||||||
No | 0.000 | Reference | 0.000 | Reference | 0.000 | Reference | 0.000 | Reference |
Yes | −0.052 | −0.085, −0.019 | −0.051 | −0.084, −0.018 | −0.008 | −0.228, 0.212 | −0.001 | −0.215, 0.214 |
Caffeine, mgc | ||||||||
1st quartile | 0.000 | Reference | 0.000 | Reference | 0.000 | Reference | 0.000 | Reference |
2nd quartile | −0.009 | −0.059, 0.040 | −0.012 | −0.062, 0.039 | −0.029 | −0.135, 0.077 | −0.048 | −0.156, 0.060 |
3rd quartile | −0.029 | −0.067, 0.010 | −0.030 | −0.071, 0.010 | −0.058 | −0.176, 0.061 | −0.079 | −0.199, 0.041 |
4th quartile | −0.019 | −0.062, 0.024 | −0.023 | −0.067, 0.022 | 0.016 | −0.127, 0.159 | −0.020 | −0.163, 0.124 |
Menopausal status/hormone use (women only) | ||||||||
Premenopausal | 0.000 | Reference | 0.000 | Reference | 0.000 | Reference | 0.000 | Reference |
Postmenopausal/Never used | 0.037 | −0.046, 0.121 | 0.039 | −0.049, 0.128 | −0.185 | −0.419, 0.049 | −0.171 | −0.402, 0.060 |
Postmenopausal/Past, not current | −0.018 | −0.087, 0.051 | −0.003 | −0.081, 0.076 | −0.068 | −0.321, 0.184 | −0.040 | −0.305, 0.224 |
Postmenopausal/Past, unknown current | −0.006 | −0.102, 0.090 | −0.006 | −0.094, 0.081 | −0.187 | −0.457, 0.083 | −0.012 | −0.292, 0.268 |
Postmenopausal/Current | NA | NA | NA | NA |
Abbreviations: CI, Confidence Interval; MEHP, mono-2-ethylhexyl phthalate; MEHHP, mono-(2-ethyl-5-hydroxyhexyl) phthalate; %MEHP, ratio of MEHP to the sum of the secondary metabolites; NA, Not Applicable
Adjusted for age, BMI, and race
Adjusted for age, BMI, race, and all other factors in the analyses
1st quartile <10; 2nd quartile 10−<91 ; 3rd quartile 91−<208; and 4th quartile >208 mg