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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Lancet Psychiatry. 2017 Apr 26;4(6):469–476. doi: 10.1016/S2215-0366(17)30130-X

Table 4.

Alcohol Dependence at Wave 2, by WHO1 drinking risk level at Wave 1 and change in WHO level, Wave 1 to Wave 2

All Wave 1 Drinkers (n=22 005): Wave 1 drinkers with Alcohol Dependence (n=1 152)
Wave 1 WHO risk level Wave 2 change in WHO level % with Wave 2 Alcohol Dependence2 aOR3 (95% CI) p-value 1 Wave 1 WHO risk level Wave 2 change in WHO level % with Wave 2 Alcohol Dependence2 aOR3 (95% CI) p-value
Very High (n=512) Very High (n=276)
no change 36.57 reference no change 77.35 reference
decrease 1 13.54 0.27 (0.18–0.41) <0.0001 decrease 1 49.59 0.29 (0.15–0.57) 0.00030
decrease 2 08.83 0.17 (0.10–0.27) <0.0001 decrease 2 18.11 0.06 (0.04–0.10) < 0.0001
decrease 3 03.78 0.07 (0.05–0.10) <0.0001 decrease 3 12.30 0.04 (0.03–0.06) < 0.0001
abstainer 00.00 abstainer 00.00
High (n=546) High (n=153)
increase 21.99 0.76 (0.52–1.11) 0.15 increase 53.97 0.95 (0.48–1.87) 0.88
no change 27.17 reference no change 55.24 reference
decrease 1 19.21 0.64 (0.54–0.75) <0.0001 decrease 1 24.94 0.27 (0.16–0.45) < 0.0001
decrease 2 04.12 0.12 (0.09–0.15) <0.0001 decrease 2 11.21 0.10 (0.06–0.16) < 0.0001
abstainer 00.00 abstainer 00.00
Moderate (n=1 073) Moderate (n=175)
increase 20.56 1.44 (1.06–1.95) 0.019 increase 48.17 2.21(1.45–3.38) 0.00023
no change 15.25 reference no change 29.57 reference
decrease 1 04.98 0.29 (0.23–0.37) <0.0001 decrease 1 12.64 0.34 (0.24–0.49) < 0.0001
abstainer 00.00 abstainer 00.00
Low (n=19 874) Low (n=548)
increase 19.02 8.23 (7.26–9.32) <0.0001 increase 37.79 3.82 (2.98–4.88) < 0.0001
no change 02.78 reference no change 13.73 reference
abstainer 00.00 abstainer 00.00
1

WHO World Health Organization

2

The percentages in this column indicate the % of respondents in each row (representing a WHO risk drinking category at Wave 1) who had alcohol dependence at Wave 2 based on the logistic regression model that included adjustment for covariates fixed at their marginal distributions found in the sample. For example, among all participants who were very high risk drinkers at Wave 1, an estimated 36.57% of those whose risk level did not change by Wave 2 had alcohol dependence at Wave 2; among participants who were very high risk drinkers and also alcohol dependent at Wave 1, an estimated 77.35% of those whose risk level did not change by Wave 2 had alcohol dependence at Wave 2.

3

aOR = adjusted odds ratio. Odds ratios indicate the effect of the predictor variable (change in WHO risk drinking level) on the outcome (Wave 2 alcohol dependence), relative to a comparison group (in this case, participants whose WHO risk drinking level did not change between Waves 1 and 2). Odds ratios >1.00 indicate increased odds relative to the comparison group, Odds ratios=1.00 indicate no difference in risk, and odds ratios <1.00 indicate decreased risk relative to the comparison group. Statistical significance of an aOR is indicated by a 95% confidence interval that does not include 1.00 between its lower and upper limit.