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. Author manuscript; available in PMC: 2018 Jun 15.
Published in final edited form as: Cell. 2017 Jun 15;169(7):1177–1186. doi: 10.1016/j.cell.2017.05.038

Figure 2.

Figure 2

Heritability tends to be enriched in regions that are transcriptionally active in relevant tissues. (a) Contributions to heritability (relative to random SNPs) as a function of chromatin context. There is enrichment for signal among SNPs that are in chromatin active in the relevant tissue, regardless of the overall tissue breadth of activity. (b) Genes with brain-specific expression show the strongest enrichment of schizophrenia signal (left), but broadly expressed genes contribute more to total heritability due to their greater number (right).