Fig. 3.

Augmented oxidoreductase activity and glutathione metabolism. A) Heat map illustrating RNAseq derived log2 expression changes of the top 25 DEG's contained within IPA's biological function of free radical scavenging. Red values indicate upregulation, black values indicate either unchanged or insignificant change, and blue indicates downregulated expression when compared to non-transgenic mice (NTG). B) Real-time qPCR validation of 4 genes within the free radical scavenging category. C) Heat map illustrating RNAseq derived log2 expression changes of the top 25 DEG's contained within IPA's biological function of drug metabolism and protein synthesis. Real-time qPCR validation of 4 genes within the drug metabolism and protein synthesis category. In panels B & D, the expression levels of genes were normalized to Gapdh and/or Arbp1/Rplp0 house-keeping genes. *p < 0.05, **p < 0.01, ***p < 0.001. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)