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. 2017 Jul 24;13:568–580. doi: 10.1016/j.redox.2017.07.013

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© 2017 Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 6 — Aberrant antioxidant signaling and impaired protein quality control in RS hearts. A) Heat map illustrating RNA sequencing log2 expression changes of the top 25 DEG's contained within IPA's biological function of cardiovascular system development and function. B) Real-time qPCR validation of 4 genes within the cardiovascular system development and function. C) Heat map illustrating RNA sequencing log2 expression changes of the top 25 DEG's contained within IPA's biological function of cardiovascular disease. D) Real-time qPCR validation of 4 genes within the cardiovascular disease category. E) Heat map illustrating RNA sequencing log2 expression changes of the top 25 DEG's contained within IPA's biological function of cell death. F) Real-time qPCR validation of 4 genes within the cell death category. In panels B, D, & F, the expression levels of genes were normalized to Gapdh and/or Arbp1/Rplp0 house-keeping genes. *p < 0.05, **p < 0.01, ***p < 0.001.